منابع مشابه
Arabidopsis MSI1 connects LHP1 to PRC2 complexes.
Polycomb group (PcG) proteins form essential epigenetic memory systems for controlling gene expression during development in plants and animals. However, the mechanism of plant PcG protein functions remains poorly understood. Here, we probed the composition and function of plant Polycomb repressive complex 2 (PRC2). This work established the fact that all known plant PRC2 complexes contain MSI1...
متن کاملRYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3
Polycomb-repressive complex 1 (PRC1) has a central role in the regulation of heritable gene silencing during differentiation and development. PRC1 recruitment is generally attributed to interaction of the chromodomain of the core protein Polycomb with trimethyl histone H3K27 (H3K27me3), catalyzed by a second complex, PRC2. Unexpectedly we find that RING1B, the catalytic subunit of PRC1, and ass...
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هدف از این مطالعه طراحی یک روش کلی برای سنتز یک سری از کمپلکس های دو هسته ای متقارن سیکلومتاله شده پلاتین (ii) بوده که دارای یک لیگاند پل زن(1,2-bis[bis(pentafluoro-phenyl)phosphino]ethane),dfppe, است. از واکنش cis-[pt(r)2(sme2)2]، که در آنr= para-tolyl ، با یک اکی والان از لیگاند benzo[h]quinoline,bhq، در استون محصول [pt(r)(bhq)(sme2)] که در آن r= para-tolyl بدست می آید. همچنین از واکنش 5/0 اک...
architecture and engineering of nanoscale sculptured thin films and determination of their properties
چکیده ندارد.
15 صفحه اولJarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2
The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental gene regulation in multicellular organisms. PRC1 and PRC2 modify chromatin by catalysing histone H2A lysine 119 ubiquitylation (H2AK119u1), and H3 lysine 27 methylation (H3K27me3), respectively. Reciprocal crosstalk between these modifications is critical for the formation of stable Polycomb domains at target g...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2018
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2018.04.009